Filmmaker Kalpana Lajmi died on Sunday morning at the Kokilaben Dhirubhai Ambani Hospital here, a family member said.
She was 64.
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Lajmi suffered from chronic kidney disease and liver failure.
'She was on dialysis. She has been in and out of the hospital for three years. The last rites will be possibly conducted today,' her brother Dev Lajmi said.
Lajmi, a director, producer and screenwriter, was known for putting women at the centre of her stories. She made Rudaali, Daman and Darmiyaan.
Lajmi's last movie as a director was Chingaari in 2006, based on the novel The Prostitute and the Postman by Bhupen Hazarika, who was her partner.